The relationship between inflammatory marker levels and HBV-related cirrhosis severity

Haematological indices, including neutrophil-lymphocyte ratio (NLR), red blood cell distribution width (RDW), and red blood cell distribution width-platelet ratio (RPR) are used to assess the severity of various diseases. We aim to evaluate the relationship between these parameters and the severity of Hepatitis B Virus (HBV) related cirrhosis. The study consisted of 78 patients with HBV-related cirrhosis (32 compensated and 46 decompensated patients) and 54 healthy individuals. Clinical characteristics and laboratory parameters were recorded. The NLR, RDW and RPR were significantly increased in cirrhosis patients. The NLR in decompensated were significantly higher than compensated cirrhosis (3.84 ± 3.27 vs. 1.71 ± 0.65, P < 0.001). Moreover, RDW and RPR were significantly increased in decompensated patients compared to the compensated cirrhosis patients (all P < 0.001). The area under the curve of NLR was 0.801 and received a cutoff value of 2.06 (71.7% sensitivity and 78.1% specificity). The AUC values of RDW and RPR were 0.815 (cutoff value: 15.5%; sensitivity: 76.1%; specificity: 75.0%) and 0.876 (cutoff value: 0.166; sensitivity: 93.5%; specificity: 75.0%), respectively. The NLR, RDW and RPR were significantly increased and associated with disease severity in HBV-related cirrhosis patients.